93,470 XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 9.35 per share. | 28 Feb 2025 | 2,178 | 1,778,144 (2%) | 0% | 9.3 | 20,364 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 75,000 | 374,038 (0%) | 0% | 0 | Ordinary Shares | |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 75,000 | 374,138 (0%) | 0% | 0 | Ordinary Shares | |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 75,000 | 393,811 (0%) | 0% | 0 | Ordinary Shares | |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 75,000 | 214,261 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.66 per share. | 20 Feb 2025 | 35,129 | 1,775,966 (2%) | 0% | 9.7 | 339,346 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.66 per share. | 20 Feb 2025 | 13,751 | 299,138 (0%) | 0% | 9.7 | 132,835 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.66 per share. | 20 Feb 2025 | 14,534 | 318,811 (0%) | 0% | 9.7 | 140,398 | Ordinary Shares |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.66 per share. | 20 Feb 2025 | 11,295 | 139,261 (0%) | 0% | 9.7 | 109,110 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.66 per share. | 10 Feb 2025 | 15,810 | 299,038 (0%) | 0% | 9.7 | 152,725 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 5,283 | 314,848 (0%) | 0% | 0 | Ordinary Shares | |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 21 Jan 2025 | 4,000 | 309,565 (0%) | 0% | 9 | 36,000 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.97 per share. | 20 Nov 2024 | 15,997 | 1,811,095 (2%) | 0% | 10.0 | 159,490 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.97 per share. | 20 Nov 2024 | 9,178 | 313,565 (0%) | 0% | 10.0 | 91,505 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.97 per share. | 20 Nov 2024 | 8,477 | 312,889 (0%) | 0% | 10.0 | 84,516 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.97 per share. | 20 Nov 2024 | 9,268 | 333,345 (0%) | 0% | 10.0 | 92,402 | Ordinary Shares |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.97 per share. | 20 Nov 2024 | 10,076 | 150,556 (0%) | 0% | 10.0 | 100,458 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 9.57 per share. | 14 Nov 2024 | 3,193 | 1,827,092 (2%) | 0% | 9.6 | 30,557 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 11 Nov 2024 | 4,000 | 322,743 (0%) | 0% | 9 | 36,000 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.22 per share. | 20 Aug 2024 | 15,997 | 1,823,899 (2%) | 0% | 8.2 | 131,495 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.22 per share. | 20 Aug 2024 | 9,222 | 326,743 (0%) | 0% | 8.2 | 75,805 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.22 per share. | 20 Aug 2024 | 8,635 | 321,366 (0%) | 0% | 8.2 | 70,980 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.22 per share. | 20 Aug 2024 | 9,268 | 342,613 (0%) | 0% | 8.2 | 76,183 | Ordinary Shares |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.22 per share. | 20 Aug 2024 | 5,201 | 160,632 (0%) | 0% | 8.2 | 42,752 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 7.83 per share. | 07 Aug 2024 | 3,252 | 1,839,896 (2%) | 0% | 7.8 | 25,463 | Ordinary Shares |
| Eli Samaha | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 7.80 per share. | 07 Aug 2024 | 999,800 | 9,511,150 (15%) | 1% | 7.8 | 7,798,440 | COM |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 10 Jul 2024 | 4,000 | 335,965 (0%) | 0% | 9 | 36,000 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.10 per share. | 20 May 2024 | 15,997 | 1,836,644 (2%) | 0% | 9.1 | 145,573 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.10 per share. | 20 May 2024 | 9,268 | 339,965 (0%) | 0% | 9.1 | 84,339 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.10 per share. | 20 May 2024 | 8,635 | 330,001 (0%) | 0% | 9.1 | 78,579 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.10 per share. | 20 May 2024 | 9,268 | 351,881 (0%) | 0% | 9.1 | 84,339 | Ordinary Shares |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.10 per share. | 20 May 2024 | 5,201 | 165,833 (0%) | 0% | 9.1 | 47,329 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 9.85 per share. | 15 May 2024 | 2,068 | 1,852,641 (2%) | 0% | 9.9 | 20,370 | Ordinary Shares |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 80,555 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 80,555 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 47,416 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 63,555 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 64,331 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 31,488 (0%) | 0% | 0 | Ordinary Shares | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Jeremy Grant | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 23,576 | 23,576 | - | - | Share Option (Right to Buy) | |
| Jeremy Grant | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 10,537 | 22,305 (0%) | 0% | 0 | Ordinary Shares | |
| Eli Samaha | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 8.75 per share. | 01 May 2024 | 499,324 | 8,511,350 (13%) | 0% | 8.8 | 4,369,085 | COM |
| Eli Samaha | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 8.75 per share. | 01 May 2024 | 999,800 | 8,012,026 (12%) | 1% | 8.8 | 8,748,250 | COM |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2024 | 300,000 | 1,850,573 (2%) | 0% | 0 | Ordinary Shares | |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2024 | 37,500 | 349,233 (0%) | 0% | 0 | Ordinary Shares | |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2024 | 100,000 | 338,636 (0%) | 0% | 0 | Ordinary Shares | |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2024 | 100,000 | 360,684 (0%) | 0% | 0 | Ordinary Shares | |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2024 | 37,500 | 171,034 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Mar 2024 | 3,900 | 1,550,573 (2%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Mar 2024 | 3,900 | 3,900 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 8.64 per share. | 15 Mar 2024 | 2,704 | 1,561,473 (2%) | 0% | 8.6 | 23,363 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Mar 2024 | 7,000 | 1,554,473 (2%) | 0% | 0 | Ordinary Shares | |
| Graham Richard A. | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 19,294 | 314,915 (0%) | 0% | 8.9 | 172,102 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 17,036 | 238,636 (0%) | 0% | 8.9 | 151,961 | Ordinary Shares |
| Aine Miller | SVP, DEV & HEAD OF IRE OFFICE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 11,782 | 133,534 (0%) | 0% | 8.9 | 105,095 | Ordinary Shares |
| E. Winningham Rick | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 37,196 | 1,558,769 (2%) | 0% | 8.9 | 331,788 | Ordinary Shares |
| Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 18,219 | 312,987 (0%) | 0% | 8.9 | 162,513 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 8.71 per share. | 20 Feb 2024 | 1,254 | 311,733 (0%) | 0% | 8.7 | 10,922 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.92 per share. | 20 Feb 2024 | 17,595 | 260,684 (0%) | 0% | 8.9 | 156,947 | Ordinary Shares |
| Grant Jeremy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Dec 2023 | 6,578 | 6,578 | - | - | Share Option (Right to Buy) | |
| Jeremy Grant | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Dec 2023 | 8,826 | 8,826 (0%) | 0% | 0 | Ordinary Shares | |
| Grant Jeremy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Dec 2023 | 2,942 | 11,768 (0%) | 0% | 0 | Ordinary Shares | |
| Grant Jeremy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Dec 2023 | 19,734 | 19,734 | - | - | Share Option (Right to Buy) | |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 9.47 per share. | 22 Aug 2023 | 1,807 | 340,566 (0%) | 0% | 9.5 | 17,112 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.70 per share. | 20 Aug 2023 | 15,804 | 1,611,769 (2%) | 0% | 9.7 | 153,299 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.70 per share. | 20 Aug 2023 | 10,461 | 339,285 (0%) | 0% | 9.7 | 101,472 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.70 per share. | 20 Aug 2023 | 10,460 | 342,373 (0%) | 0% | 9.7 | 101,462 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.70 per share. | 20 Aug 2023 | 7,114 | 261,859 (0%) | 0% | 9.7 | 69,006 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.70 per share. | 20 Aug 2023 | 8,912 | 285,297 (0%) | 0% | 9.7 | 86,446 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 9.99 per share. | 11 Aug 2023 | 2,322 | 349,746 (0%) | 0% | 10.0 | 23,197 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 9.84 per share. | 14 Jul 2023 | 2,322 | 352,068 (0%) | 0% | 9.8 | 22,848 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 10.69 per share. | 14 Jun 2023 | 2,322 | 354,390 (0%) | 0% | 10.7 | 24,822 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 11.13 per share. | 08 Jun 2023 | 1,790 | 352,833 (0%) | 0% | 11.1 | 19,923 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.21 per share. | 20 May 2023 | 15,804 | 1,627,573 (2%) | 0% | 11.2 | 177,163 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.21 per share. | 20 May 2023 | 10,460 | 356,712 (0%) | 0% | 11.2 | 117,257 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.21 per share. | 20 May 2023 | 5,567 | 354,623 (0%) | 0% | 11.2 | 62,406 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.21 per share. | 20 May 2023 | 8,744 | 268,973 (0%) | 0% | 11.2 | 98,020 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.21 per share. | 20 May 2023 | 11,469 | 294,209 (0%) | 0% | 11.2 | 128,567 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 11.26 per share. | 15 May 2023 | 2,322 | 367,172 (0%) | 0% | 11.3 | 26,146 | Ordinary Shares |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 100,589 (0%) | 0% | 0 | Ordinary Shares | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 70,018 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 70,018 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 36,879 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 53,018 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 53,794 (0%) | 0% | 0 | Ordinary Shares | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 22,044 | 22,044 | - | - | Share Option (Right to Buy) | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 May 2023 | 9,132 | 20,951 (0%) | 0% | 0 | Ordinary Shares | |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 11.88 per share. | 14 Apr 2023 | 2,323 | 369,494 (0%) | 0% | 11.9 | 27,597 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 10.32 per share. | 14 Mar 2023 | 2,323 | 371,817 (0%) | 0% | 10.3 | 23,973 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 10.20 per share. | 09 Mar 2023 | 4,000 | 360,190 (0%) | 0% | 10.2 | 40,800 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 10.05 per share. | 06 Mar 2023 | 2,323 | 374,140 (0%) | 0% | 10.0 | 23,346 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 330,000 | 1,643,377 (2%) | 0% | 0 | Ordinary Shares | |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 75,000 | 376,463 (0%) | 0% | 0 | Ordinary Shares | |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 75,000 | 364,190 (0%) | 0% | 0 | Ordinary Shares | |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 80,000 | 277,717 (0%) | 0% | 0 | Ordinary Shares | |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 75,000 | 304,958 (0%) | 0% | 0 | Ordinary Shares | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 1,688 | 11,819 (0%) | 0% | 0 | Ordinary Shares | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 4,666 | 4,666 | - | - | Share Option (Right to Buy) | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Susannah Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 10,131 | 10,131 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.44 per share. | 20 Feb 2023 | 37,420 | 1,313,377 (2%) | 0% | 10.4 | 390,665 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.44 per share. | 20 Feb 2023 | 12,057 | 301,463 (0%) | 0% | 10.4 | 125,875 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.44 per share. | 20 Feb 2023 | 7,119 | 289,190 (0%) | 0% | 10.4 | 74,322 | Ordinary Shares |
| Aziz Sawaf | SVP & CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.44 per share. | 20 Feb 2023 | 6,783 | 197,717 (0%) | 0% | 10.4 | 70,815 | Ordinary Shares |
| Brett A. Grimaud | SVP, GEN COUNSEL AND SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.44 per share. | 20 Feb 2023 | 10,198 | 229,958 (0%) | 0% | 10.4 | 106,467 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 10.73 per share. | 01 Dec 2022 | 2,084 | 313,520 (0%) | 0% | 10.7 | 22,361 | Ordinary Shares |
| Donal O'Connor | Director | Sale or transfer of securities back to the company at price $ 10.50 per share. | 22 Nov 2022 | 10,000 | 43,886 (0%) | 0% | 10.5 | 105,000 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.85 per share. | 20 Nov 2022 | 15,804 | 1,409,797 (2%) | 0% | 10.8 | 171,473 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.85 per share. | 20 Nov 2022 | 27,350 | 315,604 (0%) | 0% | 10.9 | 296,748 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.85 per share. | 20 Nov 2022 | 23,268 | 296,309 (0%) | 0% | 10.9 | 252,458 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.85 per share. | 18 Nov 2022 | 25,057 | 384,714 (0%) | 0% | 10.8 | 271,868 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 11.02 per share. | 18 Nov 2022 | 65,000 | 409,771 (0%) | 0% | 11.0 | 716,242 | Ordinary Shares |
| Richard A. Graham | SVP, RESEARCH & DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.20 per share. | 16 Nov 2022 | 2,800 | 342,954 (0%) | 0% | 11.2 | 31,360 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.34 per share. | 19 Aug 2022 | 15,804 | 1,424,784 (2%) | 0% | 9.3 | 147,609 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.34 per share. | 19 Aug 2022 | 25,676 | 473,507 (0%) | 0% | 9.3 | 239,814 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.34 per share. | 19 Aug 2022 | 18,991 | 345,754 (0%) | 0% | 9.3 | 177,376 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.34 per share. | 19 Aug 2022 | 10,413 | 319,577 (0%) | 0% | 9.3 | 97,257 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 9.71 per share. | 16 Aug 2022 | 4,906 | 364,745 (0%) | 0% | 9.7 | 47,640 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 8.79 per share. | 09 Aug 2022 | 15,086 | 369,651 (0%) | 0% | 8.8 | 132,606 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2022 | 20,000 | 499,183 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.74 per share. | 20 May 2022 | 11,025 | 1,440,588 (2%) | 0% | 8.7 | 96,359 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.74 per share. | 20 May 2022 | 3,365 | 479,183 (0%) | 0% | 8.7 | 29,410 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.74 per share. | 20 May 2022 | 3,947 | 384,737 (0%) | 0% | 8.7 | 34,497 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.74 per share. | 20 May 2022 | 2,200 | 331,071 (0%) | 0% | 8.7 | 19,228 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 8.93 per share. | 20 May 2022 | 1,081 | 329,990 (0%) | 0% | 8.9 | 9,653 | Ordinary Shares |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 91,457 (0%) | 0% | 0 | Ordinary Shares | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 60,886 (0%) | 0% | 0 | Ordinary Shares | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 60,886 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 27,747 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 78,010 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 53,886 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 28,000 | 28,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 9,852 | 44,662 (0%) | 0% | 0 | Ordinary Shares | |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Sale of securities on an exchange or to another person at price $ 10.16 per share. | 28 Feb 2022 | 2,356 | 333,271 (0%) | 0% | 10.2 | 23,947 | Ordinary Shares |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 170,000 | 1,449,300 (2%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 515,000 | 515,000 | - | - | Share Option (Right to Buy) | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 22,710 | 1,279,300 (2%) | 0% | 9.6 | 218,243 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 25,973 | 481,285 (0%) | 0% | 9.6 | 249,601 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, PROD STRAT & COMM PLNG | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 27,299 | 380,123 (0%) | 0% | 9.6 | 262,343 | Ordinary Shares |
| Ann B. Brady | PRESIDENT, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 8,369 | 110,319 (0%) | 0% | 9.6 | 80,426 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 20,377 | 388,684 (0%) | 0% | 9.6 | 195,823 | Ordinary Shares |
| Rhonda Farnum | SVP, COMM & MEDICAL AFFAIRS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.61 per share. | 18 Feb 2022 | 11,824 | 335,627 (0%) | 0% | 9.6 | 113,629 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, PROD STRAT & COMM PLNG | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2022 | 52,000 | 407,422 (0%) | 0% | 0 | Ordinary Shares | |
| Rhonda Farnum | SVP, Comm & Medical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 27,500 | 347,451 (0%) | 0% | 0 | Ordinary Shares | |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2021 | 340,000 | 507,258 (0%) | 0% | 0 | Ordinary Shares | |
| Richard A. Graham | SVP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2021 | 240,000 | 409,061 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 11,404 | 1,302,010 (2%) | 0% | 8.4 | 95,337 | Ordinary Shares |
| Frank Pasqualone | SVP, CHIEF BUSINESS OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 3,779 | 429,783 (0%) | 0% | 8.4 | 31,592 | Ordinary Shares |
| Andrew A. Hindman | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 1,350 | 167,258 (0%) | 0% | 8.4 | 11,286 | Ordinary Shares |
| Philip D. Worboys | SVP, RESEARCH & TRANSL SCIENCE | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 4,310 | 330,752 (0%) | 0% | 8.4 | 36,032 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, PROD STRAT & COMM PLNG | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 4,310 | 355,422 (0%) | 0% | 8.4 | 36,032 | Ordinary Shares |
| Ann B. Brady | PRESIDENT, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 3,169 | 118,688 (0%) | 0% | 8.4 | 26,493 | Ordinary Shares |
| Vijay Sabesan | SVP, TECHNICAL OPERATIONS | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 5,191 | 235,524 (0%) | 0% | 8.4 | 43,397 | Ordinary Shares |
| Richard A. Graham | SVP, DEVELOPMENT | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.36 per share. | 19 Nov 2021 | 4,263 | - | 0% | 8.4 | 35,639 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 4,307 | 277,831 (0%) | 0% | 14.0 | 60,513 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 11,404 | 1,313,414 (2%) | 0% | 14.0 | 160,226 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 3,779 | 433,562 (0%) | 0% | 14.1 | 53,095 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 17,464 | 167,380 (0%) | 0% | 14.0 | 245,369 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 4,307 | 335,062 (0%) | 0% | 14.0 | 60,513 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 4,307 | 359,732 (0%) | 0% | 14.0 | 60,513 | Ordinary Shares |
| Ann B. Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 3,169 | 121,857 (0%) | 0% | 14.0 | 44,524 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 5,193 | 240,715 (0%) | 0% | 14.1 | 72,962 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.05 per share. | 20 Aug 2021 | 6,819 | 173,205 (0%) | 0% | 14.1 | 95,807 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 4,310 | 282,138 (0%) | 0% | 17.8 | 76,718 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 11,404 | 1,324,818 (2%) | 0% | 17.8 | 202,991 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 3,779 | 437,341 (0%) | 0% | 17.8 | 67,266 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 942 | 184,844 (0%) | 0% | 17.8 | 16,768 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 4,310 | 339,369 (0%) | 0% | 17.8 | 76,718 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 4,310 | 364,039 (0%) | 0% | 17.8 | 76,718 | Ordinary Shares |
| Ann B. Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 3,169 | 125,026 (0%) | 0% | 17.8 | 56,408 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 5,194 | 245,908 (0%) | 0% | 17.8 | 92,453 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.80 per share. | 20 May 2021 | 3,410 | 180,024 (0%) | 0% | 17.8 | 60,698 | Ordinary Shares |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 81,605 (0%) | 0% | 0 | Ordinary Shares | |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 51,034 (0%) | 0% | 0 | Ordinary Shares | |
| George M. Whitesides | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 9,828 (0%) | 0% | 0 | Ordinary Shares | |
| George M. Whitesides | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Robert V. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 68,093 (0%) | 0% | 0 | Ordinary Shares | |
| Robert V. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 51,034 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 17,895 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 68,158 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 44,034 (0%) | 0% | 0 | Ordinary Shares | |
| Susan M. Molineaux | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 9,828 (0%) | 0% | 0 | Ordinary Shares | |
| Susan M. Molineaux | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2021 | 9,828 | 34,810 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Research & Transl Science | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 09 Mar 2021 | 8,829 | 343,679 (0%) | 0% | 20 | 176,580 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 31,869 | 285,047 (0%) | 0% | 18.8 | 598,819 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 110,348 | 1,334,821 (2%) | 0% | 18.8 | 2,073,439 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 26,961 | 439,719 (0%) | 0% | 18.8 | 506,597 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 3,984 | 184,704 (0%) | 0% | 18.8 | 74,859 | Ordinary Shares |
| Brett K. Haumann | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 35,672 | 242,499 (0%) | 0% | 18.8 | 670,277 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 31,887 | 352,508 (0%) | 0% | 18.8 | 599,157 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 31,931 | 368,349 (0%) | 0% | 18.8 | 599,983 | Ordinary Shares |
| Ann B. Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 10,092 | 128,195 (0%) | 0% | 18.8 | 189,629 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 8,343 | 249,701 (0%) | 0% | 18.8 | 156,765 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.79 per share. | 20 Feb 2021 | 6,597 | 182,152 (0%) | 0% | 18.8 | 123,958 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 316,916 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 170,000 | 1,445,169 (2%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 466,680 (0%) | 0% | 0 | Ordinary Shares | |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 188,688 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Research & Transl Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 384,395 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 400,280 (0%) | 0% | 0 | Ordinary Shares | |
| Ann B. Brady | President, TBIL | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 40,000 | 138,287 (0%) | 0% | 0 | Ordinary Shares | |
| Vijay Sabesan | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 258,044 (0%) | 0% | 0 | Ordinary Shares | |
| Richard A. Graham | SVP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 65,000 | 188,749 (0%) | 0% | 0 | Ordinary Shares | |
| Richard A. Graham | SVP, Development | Sale of securities on an exchange or to another person at price $ 19.47 per share. | 14 Dec 2020 | 7,500 | 123,749 (0%) | 0% | 19.5 | 146,058 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 03 Dec 2020 | 4,246 | 319,395 (0%) | 0% | 18 | 76,428 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 4,807 | 251,916 (0%) | 0% | 17.2 | 82,728 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 13,946 | 1,275,169 (2%) | 0% | 17.2 | 240,011 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 4,214 | 401,680 (0%) | 0% | 17.2 | 72,523 | Ordinary Shares |
| Brett K. Haumann | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 4,639 | 278,171 (0%) | 0% | 17.2 | 79,837 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 4,807 | 323,641 (0%) | 0% | 17.2 | 82,728 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 4,807 | 335,280 (0%) | 0% | 17.2 | 82,728 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 2,292 | 98,287 (0%) | 0% | 17.2 | 39,445 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 3,798 | 193,044 (0%) | 0% | 17.2 | 65,364 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.21 per share. | 20 Nov 2020 | 3,876 | 131,249 (0%) | 0% | 17.2 | 66,706 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2020 | 27,500 | 135,125 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,804 | 256,723 (0%) | 0% | 18.2 | 87,529 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 13,946 | 1,289,115 (2%) | 0% | 18.2 | 254,096 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,214 | 405,894 (0%) | 0% | 18.2 | 76,779 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,323 | 123,135 (0%) | 0% | 18.2 | 78,765 | Ordinary Shares |
| Brett K. Haumann | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,646 | 307,810 (0%) | 0% | 18.2 | 84,650 | Ordinary Shares |
| Brett K. Haumann | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.29 per share. | 20 Aug 2020 | 25,000 | 282,810 (0%) | 0% | 18.3 | 457,240 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 20 Aug 2020 | 17,103 | 333,252 (0%) | 0% | 18 | 307,854 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,804 | 328,448 (0%) | 0% | 18.2 | 87,529 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 4,804 | 340,087 (0%) | 0% | 18.2 | 87,529 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 2,292 | 100,579 (0%) | 0% | 18.2 | 41,760 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 3,799 | 196,842 (0%) | 0% | 18.2 | 69,218 | Ordinary Shares |
| Richard A. Graham | SVP, Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.22 per share. | 20 Aug 2020 | 6,598 | 107,625 (0%) | 0% | 18.2 | 120,216 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jul 2020 | 20,000 | 127,458 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2020 | 8,067 | 8,067 (0%) | 0% | 0 | Ordinary Shares | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2020 | 5,000 | 5,000 | - | - | Share Option (Right to Buy) | |
| Deepika Rachel Pakianathan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2020 | 12,000 | 12,000 | - | - | Share Option (Right to Buy) | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 4,807 | 261,527 (0%) | 0% | 26.7 | 128,203 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 13,946 | 1,303,061 (2%) | 0% | 26.7 | 371,940 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 4,214 | 410,108 (0%) | 0% | 26.7 | 112,387 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 4,212 | 312,456 (0%) | 0% | 26.7 | 112,334 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 4,807 | 350,355 (0%) | 0% | 26.7 | 128,203 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 4,807 | 344,891 (0%) | 0% | 26.7 | 128,203 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 2,292 | 102,871 (0%) | 0% | 26.7 | 61,128 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.67 per share. | 20 May 2020 | 3,801 | 200,641 (0%) | 0% | 26.7 | 101,373 | Ordinary Shares |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 71,777 (0%) | 0% | 0 | Ordinary Shares | |
| Burton G. Malkiel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 41,206 (0%) | 0% | 0 | Ordinary Shares | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| George M. Whitesides | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| George M. Whitesides | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 6,635 (0%) | 0% | 0 | Ordinary Shares | |
| Robert V. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 58,265 (0%) | 0% | 0 | Ordinary Shares | |
| Robert V. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 41,206 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| William D. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 58,330 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 34,206 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Susan M. Molineaux | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 6,635 (0%) | 0% | 0 | Ordinary Shares | |
| Susan M. Molineaux | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,635 | 24,982 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 29,402 | 264,932 (0%) | 0% | 25.9 | 761,512 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 96,850 | 1,315,605 (2%) | 0% | 25.9 | 2,508,415 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 24,392 | 412,920 (0%) | 0% | 25.9 | 631,753 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 7,060 | 106,490 (0%) | 0% | 25.9 | 182,854 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 33,608 | 316,668 (0%) | 0% | 25.9 | 870,447 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 29,105 | 354,750 (0%) | 0% | 25.9 | 753,820 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 29,136 | 349,698 (0%) | 0% | 25.9 | 754,622 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 5,948 | 105,163 (0%) | 0% | 25.9 | 154,053 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.90 per share. | 20 Feb 2020 | 7,213 | 203,040 (0%) | 0% | 25.9 | 186,817 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 240,334 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 54,000 | 294,334 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 170,000 | 1,244,455 (1%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 168,000 | 1,412,455 (2%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 54,000 | 437,312 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 383,312 (0%) | 0% | 0 | Ordinary Shares | |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 43,550 | 93,550 (0%) | 0% | 0 | Ordinary Shares | |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 20,000 | 113,550 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 54,000 | 350,276 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 296,276 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Research & Transl Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 54,000 | 383,855 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Research & Transl Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 329,855 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 54,000 | 378,834 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 324,834 (0%) | 0% | 0 | Ordinary Shares | |
| Ann Brady | President, TBIL | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 40,000 | 111,111 (0%) | 0% | 0 | Ordinary Shares | |
| Vijay Sabesan | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 65,000 | 210,253 (0%) | 0% | 0 | Ordinary Shares | |
| Vijay Sabesan | SVP, Technical Operations | Sale of securities on an exchange or to another person at price $ 21.03 per share. | 12 Dec 2019 | 1,027 | 145,253 (0%) | 0% | 21.0 | 21,598 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 3,567 | 175,334 (0%) | 0% | 17.6 | 62,779 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 8,678 | 1,074,455 (1%) | 0% | 17.6 | 152,733 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 2,447 | 318,312 (0%) | 0% | 17.6 | 43,067 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 2,692 | 231,276 (0%) | 0% | 17.6 | 47,379 | Ordinary Shares |
| Philip D. Worboys | SVP, Research & Transl Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 2,272 | 264,855 (0%) | 0% | 17.6 | 39,987 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 2,272 | 259,834 (0%) | 0% | 17.6 | 39,987 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 1,073 | 71,111 (0%) | 0% | 17.6 | 18,885 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.60 per share. | 20 Nov 2019 | 1,473 | 146,280 (0%) | 0% | 17.6 | 25,925 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 3,084 | 178,901 (0%) | 0% | 21.5 | 66,337 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 8,678 | 1,083,133 (1%) | 0% | 21.5 | 186,664 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 2,335 | 320,759 (0%) | 0% | 21.5 | 50,226 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 2,710 | 233,968 (0%) | 0% | 21.5 | 58,292 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 2,272 | 259,900 (0%) | 0% | 21.5 | 48,871 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 2,272 | 267,127 (0%) | 0% | 21.5 | 48,871 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 2,272 | 262,106 (0%) | 0% | 21.5 | 48,871 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 1,073 | 72,184 (0%) | 0% | 21.5 | 23,080 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 20 Aug 2019 | 1,472 | 147,753 (0%) | 0% | 21.5 | 31,663 | Ordinary Shares |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2019 | 50,000 | 50,000 (0%) | 0% | 0 | Ordinary Shares | |
| Andrew A. Hindman | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2019 | 260,000 | 260,000 | - | - | Share Option (Right to Buy) | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 2,488 | 181,985 (0%) | 0% | 19.8 | 49,362 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 8,678 | 1,091,811 (1%) | 0% | 19.8 | 172,172 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 1,604 | 323,094 (0%) | 0% | 19.8 | 31,823 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 2,705 | 236,678 (0%) | 0% | 19.8 | 53,667 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 2,272 | 262,172 (0%) | 0% | 19.8 | 45,076 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 2,272 | 269,399 (0%) | 0% | 19.8 | 45,076 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 2,272 | 264,378 (0%) | 0% | 19.8 | 45,076 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 1,073 | 73,257 (0%) | 0% | 19.8 | 21,288 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.84 per share. | 20 May 2019 | 1,474 | 149,225 (0%) | 0% | 19.8 | 29,244 | Ordinary Shares |
| Donal O'Connor | None | Sale of securities on an exchange or to another person at price $ 21.00 per share. | 16 May 2019 | 1,327 | 30,244 (0%) | 0% | 21 | 27,867 | Ordinary Shares |
| Donal O'Connor | None | Sale of securities on an exchange or to another person at price $ 20.19 per share. | 16 May 2019 | 2,673 | 27,571 (0%) | 0% | 20.2 | 53,968 | Ordinary Shares |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 65,142 (0%) | 0% | 0 | Ordinary Shares | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 34,571 (0%) | 0% | 0 | Ordinary Shares | |
| Dean Jonathan Mitchell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| George M. Whitesides | None | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Apr 2019 | 21,012 | 27,650 (0%) | 0% | 0 | Ordinary Shares | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 200,963 (0%) | 0% | 0 | Ordinary Shares | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 51,630 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 34,571 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 51,695 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 37,999 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 31,571 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Susan M. Molineaux | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Susan M. Molineaux | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 8,385 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2019 | 8,385 | 18,347 (0%) | 0% | 0 | Ordinary Shares | |
| Sharath S. Hegde | SVP, Research | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 04 Mar 2019 | 5,690 | 264,444 (0%) | 0% | 24.5 | 139,405 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Sale of securities on an exchange or to another person at price $ 25.06 per share. | 04 Mar 2019 | 3,343 | 270,134 (0%) | 0% | 25.1 | 83,764 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 5,798 | 183,446 (0%) | 0% | 27 | 156,546 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 13,477 | 1,099,462 (1%) | 0% | 27 | 363,879 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 4,919 | 323,671 (0%) | 0% | 27 | 132,813 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 7,778 | 239,383 (0%) | 0% | 27 | 210,006 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 3,770 | 273,477 (0%) | 0% | 27 | 101,790 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 3,986 | 270,644 (0%) | 0% | 27 | 107,622 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 3,674 | 266,650 (0%) | 0% | 27 | 99,198 | Ordinary Shares |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 5,763 | 97,198 (0%) | 0% | 27 | 155,601 | Ordinary Shares |
| Ann Brady | President, TBIL | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 3,023 | 74,330 (0%) | 0% | 27 | 81,621 | Ordinary Shares |
| Vijay Sabesan | SVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.00 per share. | 20 Feb 2019 | 4,568 | 149,672 (0%) | 0% | 27 | 123,336 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 189,244 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 141,994 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 170,000 | 965,939 (1%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 147,000 | 1,112,939 (1%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 328,590 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 281,340 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 199,911 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 247,161 (0%) | 0% | 0 | Ordinay Shares | |
| Sharath S. Hegde | SVP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 277,247 (0%) | 0% | 0 | Ordinary Shares | |
| Sharath S. Hegde | SVP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 229,997 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Translational Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 274,630 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Translational Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 227,380 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 47,250 | 270,324 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 65,000 | 223,074 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 7,006 | 76,994 (0%) | 0% | 24.8 | 173,679 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 15,557 | 795,939 (1%) | 0% | 24.8 | 385,658 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 5,735 | 216,340 (0%) | 0% | 24.8 | 142,171 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 6,697 | 157,657 (0%) | 0% | 24.8 | 166,019 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 7,368 | 134,911 (0%) | 0% | 24.8 | 182,653 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 4,063 | 164,997 (0%) | 0% | 24.8 | 100,722 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 4,373 | 162,380 (0%) | 0% | 24.8 | 108,407 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.79 per share. | 20 Nov 2018 | 3,908 | 158,074 (0%) | 0% | 24.8 | 96,879 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Sale of securities on an exchange or to another person at price $ 28.50 per share. | 12 Sep 2018 | 6,393 | 166,753 (0%) | 0% | 28.5 | 182,201 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 27.71 per share. | 27 Aug 2018 | 7,119 | 84,000 (0%) | 0% | 27.7 | 197,282 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 7,005 | 91,119 (0%) | 0% | 27.0 | 188,785 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 15,557 | 904,063 (1%) | 0% | 26.9 | 419,261 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 5,735 | 222,075 (0%) | 0% | 26.9 | 154,558 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 6,695 | 164,354 (0%) | 0% | 26.9 | 180,430 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 6,683 | 142,279 (0%) | 0% | 27.0 | 180,107 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 5,198 | 169,060 (0%) | 0% | 26.9 | 140,086 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 5,508 | 173,146 (0%) | 0% | 27.0 | 148,441 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.95 per share. | 20 Aug 2018 | 5,043 | 161,982 (0%) | 0% | 27.0 | 135,909 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.74 per share. | 14 Aug 2018 | 2,204 | 212,588 (0%) | 0% | 27.7 | 61,136 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.43 per share. | 14 Aug 2018 | 1,700 | 171,049 (0%) | 0% | 27.4 | 46,623 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.71 per share. | 14 Aug 2018 | 39,839 | 172,749 (0%) | 0% | 26.7 | 1,064,032 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 07 Aug 2018 | 4,127 | 123,479 (0%) | 0% | 28.0 | 115,686 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 28.99 per share. | 07 Aug 2018 | 1,818 | 127,606 (0%) | 0% | 29.0 | 52,707 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 27.85 per share. | 07 Aug 2018 | 25,355 | 98,124 (0%) | 0% | 27.9 | 706,182 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 24.09 per share. | 06 Jun 2018 | 10,140 | 133,324 (0%) | 0% | 24.1 | 244,268 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 23.66 per share. | 06 Jun 2018 | 3,900 | 129,424 (0%) | 0% | 23.7 | 92,260 | Ordinary Shares |
| Burton G. Malkiel | None | Purchase of securities on an exchange or from another person at price $ 22.54 per share. | 21 May 2018 | 1,000 | 56,757 (0%) | 0% | 22.5 | 22,540 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 21,812 | 143,464 (0%) | 0% | 24.3 | 530,250 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 67,617 | 919,620 (1%) | 0% | 24.3 | 1,643,769 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 18,424 | 227,810 (0%) | 0% | 24.3 | 447,887 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 26,991 | 148,962 (0%) | 0% | 24.3 | 656,151 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 19,103 | 174,258 (0%) | 0% | 24.3 | 464,394 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 19,524 | 178,654 (0%) | 0% | 24.3 | 474,628 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 20 May 2018 | 18,779 | 167,025 (0%) | 0% | 24.3 | 456,517 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.29 per share. | 18 May 2018 | 10,000 | 236,022 (0%) | 0% | 24.3 | 242,877 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.31 per share. | 18 May 2018 | 21,230 | 214,792 (0%) | 0% | 24.3 | 516,101 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 165,276 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 105,000 | 987,237 (1%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 246,234 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 246,022 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 175,953 (0%) | 0% | 0 | Ordinary Shares | |
| Sharath S. Hegde | SVP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 193,361 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Translational Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 198,178 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 33,750 | 185,804 (0%) | 0% | 0 | Ordinary Shares | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 55,757 (0%) | 0% | 0 | Ordinary Shares | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Dean Jonathan Mitchell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 26,186 (0%) | 0% | 0 | Ordinary Shares | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 192,578 (0%) | 0% | 0 | Ordinary Shares | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 43,245 (0%) | 0% | 0 | Ordinary Shares | |
| Eran Broshy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Eran Broshy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 26,186 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 43,310 (0%) | 0% | 0 | Ordinary Shares | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 29,614 (0%) | 0% | 0 | Ordinary Shares | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Donal O'Connor | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 23,186 (0%) | 0% | 0 | Ordinary Shares | |
| Donal O'Connor | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Susan M. Molineaux | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Susan M. Molineaux | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 14,186 (0%) | 0% | 0 | Ordinary Shares | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 6,000 | 6,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2018 | 8,186 | 9,962 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 5,587 | 130,661 (0%) | 0% | 29.1 | 162,526 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 13,005 | 881,372 (1%) | 0% | 29.1 | 378,315 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 4,741 | 211,619 (0%) | 0% | 29.1 | 137,916 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 5,387 | 211,407 (0%) | 0% | 29.1 | 156,708 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 8,293 | 142,203 (0%) | 0% | 29.1 | 241,243 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 4,349 | 159,611 (0%) | 0% | 29.1 | 126,512 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 4,566 | 163,563 (0%) | 0% | 29.1 | 132,825 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 4,252 | 152,054 (0%) | 0% | 29.1 | 123,691 | Ordinary Shares |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.09 per share. | 20 Feb 2018 | 8,770 | 101,230 (0%) | 0% | 29.1 | 255,119 | Ordinary Shares |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2018 | 1,500 | 1,500 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2018 | 12,000 | 12,000 | - | - | Share Option (Right to Buy) | |
| Laurie Smaldone Alsup | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2018 | 1,776 | 1,776 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 136,248 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 28,000 | 894,377 (1%) | 0% | 0 | Ordinary Shares | |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 216,360 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 216,794 (0%) | 0% | 0 | Ordinary Shares | |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 150,496 (0%) | 0% | 0 | Ordinary Shares | |
| Sharath S. Hegde | SVP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 163,960 (0%) | 0% | 0 | Ordinary Shares | |
| Philip D. Worboys | SVP, Translational Science | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 168,129 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 9,000 | 156,306 (0%) | 0% | 0 | Ordinary Shares | |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 65,000 | 85,000 (0%) | 0% | 0 | Ordinary Shares | |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2018 | 25,000 | 110,000 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 7,079 | 127,248 (0%) | 0% | 28.6 | 202,318 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 5,820 | 207,360 (0%) | 0% | 28.6 | 166,336 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 6,753 | 207,794 (0%) | 0% | 28.6 | 193,001 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 7,846 | 141,496 (0%) | 0% | 28.6 | 224,239 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 5,177 | 154,960 (0%) | 0% | 28.6 | 147,959 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 5,503 | 159,129 (0%) | 0% | 28.6 | 157,276 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.58 per share. | 20 Nov 2017 | 5,014 | 147,306 (0%) | 0% | 28.6 | 143,300 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 30.77 per share. | 06 Sep 2017 | 14,670 | 134,327 (0%) | 0% | 30.8 | 451,350 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Purchase of securities on an exchange or from another person at price $ 26.34 per share. | 21 Aug 2017 | 4,000 | 213,180 (0%) | 0% | 26.3 | 105,359 | Ordinary Shares |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 7,079 | 148,997 (0%) | 0% | 27.4 | 193,965 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 5,820 | 209,180 (0%) | 0% | 27.4 | 159,468 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 6,752 | 214,547 (0%) | 0% | 27.4 | 185,005 | Ordinary Shares |
| Brett K. Haumann | SVP Clin Dev & Chief Med Ofc | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 7,064 | 149,342 (0%) | 0% | 27.4 | 193,554 | Ordinary Shares |
| Sharath S. Hegde | SVP, Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 5,176 | 160,137 (0%) | 0% | 27.4 | 141,822 | Ordinary Shares |
| Philip D. Worboys | SVP, Translational Science | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 5,502 | 164,632 (0%) | 0% | 27.4 | 150,755 | Ordinary Shares |
| Kenneth R. Pitzer | SVP, Prod Strat & Comm Plng | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.40 per share. | 20 Aug 2017 | 5,013 | 152,320 (0%) | 0% | 27.4 | 137,356 | Ordinary Shares |
| Burton G. Malkiel | None | Purchase of securities on an exchange or from another person at price $ 24.59 per share. | 11 Aug 2017 | 15,000 | 15,000 (0%) | 0% | 24.6 | 368,816 | Ordinary Shares |
| Burton G. Malkiel | None | Purchase of securities on an exchange or from another person at price $ 24.59 per share. | 11 Aug 2017 | 15,000 | 47,571 (0%) | 0% | 24.6 | 368,855 | Ordinary Shares |
| George M. Whitesides | None | Purchase of securities on an exchange or from another person at price $ 24.69 per share. | 11 Aug 2017 | 4,000 | 4,000 (0%) | 0% | 24.7 | 98,764 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 24.50 per share. | 11 Aug 2017 | 10,000 | 866,377 (1%) | 0% | 24.5 | 245,000 | Ordinary Shares |
| Henrietta Fore | None | Purchase of securities on an exchange or from another person at price $ 23.99 per share. | 11 Aug 2017 | 6,000 | 24,000 (0%) | 0% | 24.0 | 143,932 | Ordinary Shares |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2017 | 170,000 | 170,000 | - | - | Share Option (Right to Buy) | |
| Shehnaaz Suliman | SVP, Corp Dev & Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2017 | 20,000 | 20,000 (0%) | 0% | 0 | Ordinary Shares | |
| Bradford J. Shafer | EVP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.83 per share. | 20 May 2017 | 7,079 | 156,076 (0%) | 0% | 36.8 | 260,720 | Ordinary Shares |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.83 per share. | 20 May 2017 | 15,460 | 856,377 (1%) | 0% | 36.8 | 569,392 | Ordinary Shares |
| Frank Pasqualone | SVP, Chief Comm Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.83 per share. | 20 May 2017 | 5,820 | 215,000 (0%) | 0% | 36.8 | 214,351 | Ordinary Shares |
| Renee D. Gala | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.83 per share. | 20 May 2017 | 6,753 | 221,299 (0%) | 0% | 36.8 | 248,713 | Ordinary Shares |